Preparation and Characterization of Nanoparticles Using Poly(ε-caprolactone) -g- Poly(N-isopropylacrylamide) with Thermosensitive Function |
Paper ID : 1452-UFGNSM-FULL |
Authors: |
Abstract: |
The aim of this project is the preparation of biodegradable amphiphilic polymeric nanoparticles which their size change with temperature variation.Polycaprolactone (PCL) is a biodegradable and biocompatible linear polyester with good mechanical and thermoplastic properties [1].One of the most widely investigated stimuli sensitive polymers is poly(N-isopropylacrylamide). Owing to the amphiphilic characters of the monomeric unit, the PNiPAAm shows unique reversible thermosensitivity with the hydrated extended coil to globule transition by increasing temperature over its lower critical solution temperature (LCST) .Because of this reversible phase transition ,P(NIPAAm) has been widely used in the preparation of stimuliresponsive systems for biomedical applications, such as in the controlled release of drugs and tissue engineering [2]. In this work we report the synthesis of thermo-responsive poly(ε-caprolactone)-graft-N isopropylacryamid by atom transfer radical polymerization with poly(ε-caprolactone-co-α-bromo-ε- caprolactone) copolymer as macroinitiator. The nanoparticles and thermosensitive behaviors were investigated using 1H-NMR, turbidimetry, differential scanning calorimetry (DSC), dynamic light scattering (DLS),UV-Vis Spectroscopy , thermo gravimetric analysis (TGA) andX-ray diffraction (XRD) . Also the chemical structure of the polymer was verified by FT-IR spectroscopy, 1H-NMR, scanning electron microscope (SEM). |
Keywords: |
nanoparticles, thermosensitive, PCL, PNiPAAm |
Status : Paper Accepted (Poster Presentation) |