Phase Transition with Ultrasonic Waves in Antisolvent Precipitation System for Rapid Efficient Preparation Nanoparticles Suspension of Azithromycin |
Paper ID : 1380-UFGNSM-FULL |
Authors: |
Abstract: |
The aim of the present work was to prepare nanoparticles suspension by ultrasound waves in antisolvent precipitation system for enhancing availability of azithromycin (AZ), a poorly water- soluble drug. Use of high stream velocities enhances mixing of AZ ethanolic solution with water, whereas addition of polymers/surfactants inhibits/lowers the particle growth, was prepared a homogeneous solution. With ultrasound waves, phase transition was occurred and the AZ particles with size <100 nm was prepared. Several experimental parameters, such as the ratio of AZ to stabilizer, the type of stabilizer and the concentration of stabilizer, were investigated in the ethanol-deionized water system. The results showed that the best stabilizer is PVP (poly N- vinyl- 2- pyrrolidone) 1 mg/ml that the produced nano suspension had a mean particle size of 96 nm and size distribution 35- 200 nm. |
Keywords: |
Azithromycin, Nanoparticle, Ultrasound, Antisolvent, Precipitation, phase transition |
Status : Paper Accepted (Poster Presentation) |