A CATALYTIC METHOD FOR SYNTHESIS OF 4-AMINO-5PYRIMIDINECARBONITRILES USING COPPEROXIDE NANOPARTICLES |
Paper ID : 1344-UFGNSM-FULL |
Authors: |
Abstract: |
Abstract Pyrimidine is one of the most popular N-heteroaromatic compounds incorporated into the structures of many pharmaceuticals. Some such compounds are analgesics1, antihypertensives, antipyretics, and anti-inflammatory drugs2. Production of nanoparticles can be carried out by chemical and physical methods. Super Critical Water Hydrothermal Synthesis (SCWHS) is among the most active fields of green chemistry. It is a relatively simple and environmentally benign process. We first attempted synthesis of copper oxide nanoparticles by a batchwise supercritical hydrothermal method. After preparation of CuO nanoparticles and characterization by XRD, TEM techniques, they were employed as a recyclable catalyst for an efficient synthesis of 2-amino-5-pyrimidinecarbonitriles 4 via multi-component reactions of aldehydes 1, malononitrile 2 and amidines 3 (Scheme 1). Scheme 1. This protocol offers many attractive features such as reduced reaction times, higher yields and economic viability of the catalyst. The reaction proceeds under aqueous conditions and isolation of the catalyst is easily achieved. References 1. Hassan N. A. (2000), Molecules, 5, 827. 2. Smith P. A. S. and Kan R. O. (1964), J. Org. Chem, 29, 2261. |
Keywords: |
CuO Nanoparticles, Reusable Catalyst ,4-Amino-5- pyrimidinecarbonitriles |
Status : Paper Accepted (Poster Presentation) |